The table below shows the pharmacological and pharmacokinetic properties of beta-blockers. We have also compiled another table on the potency of beta-blockers compared to propranolol.
| Beta-Blockers | Cardioselective / Beta-1 Selective | ISA (Intrinsic Sympathomimetic Activity) / PAA (Partial Agonist Activity) | Lipid Solubility | Alpha Blockade | Elimination Half Life (hours) | Route of Elimination |
| Acebutolol | Yes | + | Low – Moderate | No | 3-4 (Acebutolol), 8-13 (Diacetolol) | Hepatic, Renal |
| Atenolol | Yes | – | Low | No | 6-7 | Renal |
| Bisoprolol | Yes | – | Moderate | No | 10-12 | Hepatic, Renal |
| Carvedilol | No | – | High | Yes | 6-10 | Hepatic |
| Celiprolol | Yes | + | Low | No | 5-6 | Renal |
| Metoprolol | Yes | – | Moderate | No | 3-7 | Hepatic |
| Nadolol | No | – | Low | No | 20-24 | Renal |
| Nebivolol | Yes | – | High | No | 10 (in fast metabolisers, but 3-5 times longer in slow metabolisers) | Hepatic |
| Oxprenolol | No | ++ | Moderate | No | 1-2 | Hepatic |
| Pindolol | No | +++ | Moderate | No | 3-4 | Hepatic, Renal |
| Propranolol | No | – | High | No | 3-6 | Hepatic |
| Sotalol | No | – | Low | No | 10-20 | Renal |
References:
1. Accord Healthcare Ltd. Atenolol 100mg tablets – Summary of Product Characteristics. Available at: http://www.medicines.org.uk/emc/medicine/25739 [Accessed on 17/04/19].
2. Accord Healthcare Ltd. Bisoprolol 2.5mg film coated tablets – Summary of Product Characteristics. Available at: http://www.medicines.org.uk/emc/medicine/25983 [Accessed on 17/04/19].
3. Accord Healthcare Ltd. Propranolol 40 mg film-coated tablets – Summary of Product Characteristics. Available at: http://www.medicines.org.uk/emc/medicine/27274 [Accessed on 17/04/19].
4. Accord Healthcare Ltd. Sotalol hydrochloride 160 mg tablets – Summary of Product Characteristics. Available at: http://www.medicines.org.uk/emc/medicine/25989 [Accessed on 17/04/19].
5. Accord-UK Ltd. Nebivolol 5 mg tablets – Summary of Product Characteristics. Available at: https://www.medicines.org.uk/emc/product/5828/smpc [Accessed on 17/04/19].
6. Amdipharm Mercury Company Ltd. Oxprenolol 40 mg tablets – Summary of Product Characteristics. Available at: http://www.medicines.org.uk/emc/medicine/27985 [Accessed on 17/04/19].
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8. Aurobindo Pharma – Milpharm Ltd. Metoprolol tartrate 50 mg film-coated tablets – Summary of Product Characteristics. Available at: http://www.medicines.org.uk/emc/medicine/28460 [Accessed on 17/04/19].
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15. Sanofi. Celectol 200mg tablets – Summary of Product Characteristics. Available at: https://www.medicines.org.uk/emc/product/9241/smpc [Accessed on 17/04/19].
16. Sanofi. Corgard tablets 80mg – Summary of Product Characteristics. Available at: http://www.medicines.org.uk/emc/medicine/12767
[Accessed on 17/04/19].
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