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Drug Interactions

Welcome to the drug interactions category for physicians and pharmacists. This category features links to clinical practice resources on identifying, checking and managing drug-drug including CYP450 (cytochrome P450), drug-herb and drug-food interactions.

Drug Interactions by Hansten and Horn: Current Topics in Drug Interactions

Source: hanstenandhorn.com
Clinical Resource: Journal Articles
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Drug interactions in general practice

An interaction occurs when the effects of one drug are changed by another drug, food, drink or exposure to an environmental chemical. However, not all drug interactions are clinically significant. This Bulletin discusses drug interactions and explores how they can be managed in general practice.

Source: www.webarchive.org.uk
Clinical Resource: National Prescribing Centre Bulletin
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Last Checked: 24/04/15 Link Error: Report It

 

Drug Interactions I: How They Occur

This is the first of 2 bulletins on drug interactions; it will explain the various ways that a drug interaction may occur, and describe ways of preventing or minimising their impact on the patient.

Drug Interactions II: Frequently Asked Questions

This second bulletin on drug interactions will deal with frequently occurring problems relating to potential drug interactions in clinical practice, for which the NMIC has provided practical guidance.

Source: stjames.ie
Clinical Resource: Medicines Information Centre Bulletins
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Last Checked: 23/07/13 Link Error: Report It

 

New Zealand College of Pharmacists
Introduction to Drug Interactions

To give an overview and revision of the different mechanisms of drug interactions with special reference to those interactions that are clinically significant and relevant to practice.

Source: psnz.org.nz
Clinical Resource: Module
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Last Checked: 23/07/13 Link Error: Report It

 

Clinically Important, Common Drug-Drug Interactions

The table below describes potential management strategies for 16 DDIs. It is intended to serve as an educational tool and is not intended to be a guide for medical practice. The table lists the effect (e.g., pharmacokinetic, pharmacokinetic, clinical) and mechanism of the potential DDIs in addition to the propensity for related drugs to interact and options for clinical management.

Source: crediblemeds.org
Clinical Resource: Table
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Last Checked: 22/11/13 Link Error: Report It

 

Preventing Toxic Drug Interactions and Exposures

Chapter Section Links

  • Epidemiology
  • The cytochrome p-450 monooxygenase system
  • Warfarin
  • Digoxin
  • Phenytoin
  • Theophylline
  • Antidepressants, antipsychotics, benzodiazepines, and narcotics
  • Cardiovascular drugs and statins
  • Chemotherapeutic medications
  • Protease inhibitors
  • Estrogens and corticosteroids
  • Angiotensin-converting enzyme inhibitors, potassium-sparing diuretics, and potassium supplements
  • Serotoninergic agents
  • Nonsteroidal anti-inflammatory drugs
  • Medications that prolong the qt interval
  • Medications in the elderly and in children
  • Grapefruit juice
  • Prevention
Source: clevelandclinicmeded.com
Clinical Resource: Medical Reference
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Last Checked: 23/07/13 Link Error: Report It

 

Beware the triple whammy!

ADRAC has previously warned prescribers about the 'triple whammy' - the combination of an ACE inhibitor (ACEI) or an angiotensin II receptor antagonist (A2RA), a diuretic and an NSAID (including a COX-2 selective NSAID), which may predispose vulnerable patients to renal failure.

Source: tga.gov.au
Clinical Resource: Bulletin
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Drug combinations and impaired renal function – the ‘triple whammy’

Recent studies have identified the ‘triple whammy’ in which combinations of diuretics, nonsteroidal anti-inflammatory drugs (NSAIDs), ACE inhibitors (ACEI) and/or angiotensin receptor antagonists (ARA) may impair renal function.

Source: eu.wiley.com
Clinical Resource: Journal Article
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The Triple Whammy – A Dangerous Trio

Triple Whammy – ‘three simultaneous deleterious blows with compounded effect’. This combination of medicines can result in significant patient harm; the rate of fatalities from renal failure is estimated at 10%.

Source: saferx.co.nz
Clinical Resource: Bulletin
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Last Checked: 23/07/13 Link Error: Report It

 

Cytochrome P450 Part 1: Multiplicity and Function

This review is an update of the CYP450 superfamily of drug metabolising enzymes. It comprises a brief history of CYP450 research, outlines the standard P450 nomenclature system, and describes CYP450 multiplicity, structure and function.

Cytochrome P450 Part 2: Genetics of Inter-Individual Variability

This second article in the CYP series describes current understanding of genetic variability in the major drug metabolising CYP enzymes, nomenclature used to describe variant CYP genes, and the clinical significance of such variability.

Cytochrome P450 Part 3: Impact of Drug–Drug Interactions

This final article in the series describes the issues and principles that are important in identifying and assessing drug interactions that involve CYP enzymes.

Source: shpa.org.au
Clinical Resource: Journal Articles
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Indiana University School of Medicine
Cytochrome P450 Drug Interaction Table

This table is designed as a hypothesis testing, teaching and reference tool for physicians and researchers interested in drug interactions that are the result of competition for, or effects on the human cytochrome P450 system.

The table contains lists of drugs in columns under the designation of specific cytochrome P450 isoforms. A drug appears in a column if there is published evidence that it is metabolized, at least in part, via that isoform. It does not necessarily follow that the isoform is the principal metabolic pathway in vivo, or that alterations in the rate of the metabolic reaction catalyzed by that isoform will have large effects on the pharmacokinetics of the drug.

Source: iupui.edu
Clinical Resource: Table
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Pharmacokinetics and Metabolic Drug Interactions

Pharmacokinetics and drug metabolism play an important role as determinants of in vivo drug action. The CYP450 enzyme family plays a determinant role in the biotransformation of a vast number of structurally diverse drugs. Many drug interactions are a result of the inhibition or induction of CYP enzymes. The non-compartmental pharmacokinetic analysis is the most used method for analyzing data from a drug interaction study. Compartmental analysis can be also useful and sometimes more informative than non-compartmental analysis. Many efforts to reduce polypharmacy are important, and pharmacokinetic tools used to study the mechanism of drug-drug interactions may help in a better management of pharmacotherapy including the avoidance of clinically relevant drug interactions.

Source: benthamscience.com
Clinical Resource: Journal Article
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Last Checked: 17/02/14 Link Error: Report It

 

Drug Interactions Checker - For Drugs, Food & Alcohol
Drugs.com

The Drug Interaction Checker explains the mechanism of each drug interaction, the level of significance of the interaction (major, moderate or minor), and in certain cases, can provide the recommended course of action to manage the interaction. The Drug Interaction Checker will also display any interactions between your chosen drug(s) and food.

Source: drugs.com
Clinical Resource: Database
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Last Checked: 24/02/14 Link Error: Report It

 

Drug Interaction Checker
Medscape

  • Use the search field above to look up prescription or OTC drugs, and herbal supplements
  • Add a full drug regimen and view interactions
Source: medscape.com
Clinical Resource: Database
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Last Checked: 24/02/14 Link Error: Report It

 

Food-drug interactions: Do they really matter

Educational aims

  • To have a better understanding of the types of interaction occur between food and medicines
  • To be better informed on the advice that patients should be given on drug-food interactions
Source: mcppnet.org
Clinical Resource: Journal Article
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“Food/Drug Interactions”

The objectives of this lesson are such that upon completion the participant will be able to:

  1. List the mechanism of drug/food interactions.
  2. Describe the role of cytochrome P450 in drug metabolism.
  3. Identify the drugs that can interact with grapefruit.
  4. Acknowledge the ingredients in grapefruit that may trigger interactions.
  5. Relate common herd/drug interactions.
Source: wfprofessional.com
Clinical Resource: CE / CPD / Learning
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Last Checked: 23/07/13 Link Error: Report It

 

Food–Drug Interactions
Which Ones Really Matter?

The purpose of this article is to equip pharmacists with a better understanding of drug-food interactions. This article differs from traditional reviews on this topic because the food substance is categorized individually, with the interacting drugs discussed under each heading. While there are hundreds of drug-nutrient interactions reported in the literature, the aim here is to focus on those that are more common and clinically significant.

Source: uspharmacist.com
Clinical Resource: Journal Article
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Last Checked: 23/07/13 Link Error: Report It

 

Antimicrobial Drug-Food Interaction Chart

Source: nebraskamed.com
Clinical Resource: Chart
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Tuberculosis Medication Drug and Food Interactions

Source: heartlandntbc.org
Clinical Resource: Pocket Guide
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“Is it safe to have a drink while taking medication?”

The following table provides information on the potential for interaction between alcohol and common medications.

Source: usask.ca
Clinical Resource: Drug Information Services Newsletter
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Alcohol-related Drug Interactions

There are a number of classes of drugs that can potentially interact with alcohol (e.g., antibiotics, antidepressants, sedative/hypnotics, opioids, anticoagulants, etc). The included chart summarizes common alcohol-medication interactions including precautions and recommendations for alcohol consumption.

Source: hamsnetwork.org
Clinical Resource: Detail Document
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Alcohol-medication interactions

Many medications can interact with alcohol, leading to increased risk of illness, injury, or death. For example, it is estimated that alcohol medication interactions may be a factor in at least 25 per cent of all emergency room admissions. An unknown number of less serious interactions may go unrecognized or unrecorded. This Beyond the ABCs notes some of the most significant alcohol-drug interactions. (Although alcohol can interact with illicit drugs as well, the term “drugs” is used here to refer exclusively to medications, whether prescription or non-prescription.)

Source: albertahealthservices.ca
Clinical Resource: Publication
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Guidance on the administration of medicines to inpatients believed to have consumed alcohol
Sussex Partnership NHS Foundation Trust

This guidance applies to general psychiatry units, but may not be suitable for application on specialist units caring for patients who are known alcohol abusers or are alcohol dependent.

Source: sussexpartnership.nhs.uk
Clinical Resource: Guidance
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Sex, drugs and alcohol
Drug interactions of concern to consumers

Patients often express concerns about interactions between their medicines and alcohol and any illicit drugs that they may consume. Doctors and pharmacists are also often asked about interactions, especially short courses of antibiotics, which might reduce the efficacy of oral contraceptives.

Source: nps.org.au
Clinical Resource: Journal Article
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Last Checked: 08/08/16 Link Error: Report It

 

Grapefruit/Grapefruit Juice > Grapefruit/Grapefruit Juice Drug Interaction Information for Health Professionals

Please search the database to learn more about specific drugs, including published research studies, and the potential for an interaction with grapefruit.

Source: druginteractioncenter.org
Clinical Resource: Database
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An overview of interactions between grapefruit juice and drugs

The purpose of this article is to examine the cause of this food-drug interaction, discern the list of affected medications and to equip the pharmacist with this knowledge and specify their role in counselling patients on options to avoid the possibility of a grapefruit-drug interaction.

Source: sapj.co.za
Clinical Resource: Journal Article
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Drug – Grapefruit Interactions (Review)

Grapefruit juice is a potent inhibitor of the intestinal cytochrome P-450 3A4 system (specifically: CYP3A4 - mediated drug metabolism) which is responsible for the first-pass metabolism of many medications. This interaction can lead to increases in bioavailability and corresponding increases in serum drug levels. In many cases, the increased serum drug levels can produce some readily observable symptoms.

Source: globalrph.com
Clinical Resource: Review
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Last Checked: 23/07/13 Link Error: Report It

 

Some Possible Dietary Supplement-Drug Interactions

Source: merckmanuals.com
Clinical Resource: Table
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Drug Interactions with Vitamins and Minerals

In this article, common drug interactions with vitamins and minerals are discussed, along with suggestions on how the pharmacist should manage these interactions.

Source: uspharmacist.com
Clinical Resource: Journal Article
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Last Checked: 24/02/14 Link Error: Report It

 

Herbal-Drug Interactions

The purpose of this article is to provide an evidence-based discussion and information to educate patients about potential herbal-drug interactions.

Source: inetce.com
Clinical Resource: CE / CPD / Learning
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Last Checked: 18/03/13 Link Error: Report It

 

Herbal medicines: adverse effects and drug-herb interactions

Most clinicians are oblivious to their patients’ use of herbal medicine. All medicinal agents have potentially unexpected effects including toxicity and interactions, and herbs are no different. Drug-herb interactions are based on the same pharmacokinetic and pharmacodynamic principles as drug-drug interactions. Herbal medicines do not need to be avoided, the only fundamental issue is that they should be considered as medicine and the adverse effects and potential interactions considered. Thus pharmacists and doctors should be better informed to minimise patient harm.

Source: mcppnet.org
Clinical Resource: Journal Article
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Drug interactions with complementary medicines

Health professionals are expected to be familiar with common and clinically significant complementary medicine interactions or at least know where to look them up. Knowing the dynamic and kinetic interactions associated with commonly used complementary medicines helps to identify the risk of drug interactions. Although information on complementary medicine interactions is not readily provided by the manufacturers, evidence is available by way of case reports, independent research and web based resources, which have increased in recent years. Collectively, these data make interactions with complementary medicines largely predictable and therefore preventable.

Source: nps.org.au
Clinical Resource: Journal Article
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Herbal and Dietary Supplement–Drug Interactions in Patients with Chronic Illnesses

This review focuses on the use of dietary supplements in patients with chronic conditions, in whom the risk for dietary supplement–drug interaction is the greatest.

Source: aafp.org
Clinical Resource: Journal Article
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Last Checked: 08/05/14 Link Error: Report It

 

Can patients on levothyroxine take sea kelp?
Prepared by UK Medicines Information (UKMi) pharmacists for NHS healthcare professionals

Kelp is a generic term that refers to Laminaria and Macrocystis species of brown seaweeds, although in practice the term is often used in reference to species of Fucus. The species Fucus vesiculosus, more commonly known as bladderwrack, is reported to be commonly used in the preparation of kelp products. Because of its iodine content kelp has traditionally been used as a source of iodine for thyroid deficiency and as a slimming supplement.

Source: sps.nhs.uk
Clinical Resource: Medicines Question and Answer
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Last Checked: 22/09/16 Link Error: Report It

 

Herbs for mental illness: Effectiveness and interaction with conventional medicines

The herbal remedies discussed in this article are those commonly used for psychiatric conditions. Their effectiveness and potential for adverse side effects and interactions are assessed.

Source: jfponline.com
Clinical Resource: Journal Article
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St John’s wort (Hypericum perforatum): drug interactions and clinical outcomes

The aim of this work is to identify the medicines which interact with the herbal remedy St John’s wort (SJW), and the mechanisms responsible.

Source: eu.wiley.com
Clinical Resource: Journal Article
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Herb-medicine interactions: St John’s wort (Hypericum perforatum)
Useful information for pharmacists

This information sheet identifies the principal interacting medicines and explains the basis of the interactions. It may be used, together with other information sources, as a basis to provide advice to patients.

Source: nes.scot.nhs.uk
Clinical Resource: Information Sheet
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Potentially hazardous drug interactions with psychotropics

Of the many interactions with psychotropic drugs, a minority are potentially hazardous. Most interactions are pharmacodynamic, resulting from augmented or antagonistic actions at a receptor or from different mechanisms in the same tissue. Most important pharmacokinetic interactions are due to effects on metabolism or renal excretion.

Source: apt.rcpsych.org
Clinical Resource: Journal Article
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2010 Guide to Psychiatric Drug Interactions

Similar to the 2006 version, this educational review focuses on neuropsychiatric medications but also covers all other drugs to the extent that they interact with psychiatric medications. It emphasizes the role of pharmacologic principles to guide the safe and effective use of multiple medications when such use is necessary. Consistent with these principles, this review presents tables outlining major pharmacodynamic and pharmacokinetic mechanisms mediating DDIs relevant to the patient on psychiatric medications.

Source: primarypsychiatry.com
Clinical Resource: Journal Article
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Canadian Quick Reference Guide to Psychiatric Medication

Please note, P450 & Special Considerations sections are designed to contain helpful clinical information, and are not designed to be comprehensive. Medication interactions mediated by P450 enzyme sub-systems can be derived from the P450 information sections of the guide. Selected other clinically significant medication interactions are referred to in the Special Considerations columns.

Source: mdpu.ca
Clinical Resource: Reference Guide
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Last Checked: 20/06/13 Link Error: Report It

 

Tramadol: Seizures, Serotonin Syndrome, and Coadministered Antidepressants

In this edition of The Interface, we discuss two potential adverse events related to this commonly prescribed analgesic—seizures and serotonin syndrome.

Source: nih.gov
Clinical Resource: Journal Article
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Last Checked: 07/04/14 Link Error: Report It

 

Citalopram Drug Interaction: Prolonged QT and Risk of Arrhythmia

The interaction between citalopram and omeprazole or esomeprazole has the potential to significantly increase citalopram serum levels, prolong the QT interval and increase risk of TdP. Avoid this combination if possible.

Source: usask.ca
Clinical Resource: Drug Information Services Newsletter
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Last Checked: 18/03/13 Link Error: Report It

 

Psychiatric Medications and HIV Antiretrovirals: A Guide to Interactions for Clinicians

This convenient guide is designed to provide guidance for minimizing drug interactions and more severe reactions among patients being treated with psychiatric medications in conjunction with antiretrovirals.

Source: nynjaetc.org
Clinical Resource: Guide
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Drug interactions with oral hypoglycaemic drugs

Oral hypoglycaemic drugs may interact with other drugs. Pharmacodynamic interactions occur with medications that alter blood glucose and may require the dose of the oral hypoglycaemic drug to be altered. Pharmacokinetic interactions vary with the drug group. Sulfonylureas and repaglinide are metabolised in the liver. Their plasma concentrations and activity can be reduced by drugs which induce hepatic enzymes and increased by hepatic enzyme inhibitors. Metformin is renally excreted and may have increased toxicity with drugs that impair renal function.

Source: nps.org.au
Clinical Resource: Journal Article
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Rifamycins and Anti-Diabetic Agents: Drug-Drug Interactions

A 2-sided diagram for clinicians and healthcare providers that describes drug-drug interactions of Rifamycins and Anti-Diabetic Agents.

Source: heartlandntbc.org
Clinical Resource: Diagram
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Interactions between drugs for erectile dysfunction and drugs for cardiovascular disease

The present review will focus on the effects of drugs for cardiovascular disease on erectile function and make special emphasis on the interactions of drugs for treatment of ED with drugs for treatment of heart disease.

Source: nature.com
Clinical Resource: Journal Article
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Antimicrobials and Drug Interactions

Commonly, two or more drugs given together for the same condition act quite independently of each other, (eg aspirin and a penicillin for a streptococcal throat infection). However, the concurrent use of two drugs can change the effects of both, which may be beneficial (as in the case of penicillins with probenecid), or detrimental, (as in the case of simvastatin and clarithromycin leading to elevated serum levels of simvastatin and toxicities such a as myopathy and rhabdomyolysis).

Source: asainc.net.au
Clinical Resource: Newsletter
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Last Checked: 23/07/13 Link Error: Report It

 

HIV Insite
Database of Antiretroviral Drug Interactions

This database contains drug interactions (involving at least one antiretroviral drug) that the editors have found reported in published articles, abstracts from major conferences, or information presented to the U.S. Food and Drug Administration (generally reflected in product labeling). Studies demonstrating the absence of an interaction are also included. In addition to interactions demonstrated by data, interactions inferred from predicted mechanisms of drug metabolism are included when judged to be of potential clinical significance.

Source: hivinsite.ucsf.edu
Clinical Resource: Database
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Last Checked: 23/07/13 Link Error: Report It

 

HIV Drug Interactions
University of Liverpool

We provide a clinically useful, reliable, comprehensive, up-to-date, evidence-based drug-drug interaction resource, freely available to healthcare workers, patients and researchers.

Source: hiv-druginteractions.org
Clinical Resource: Various
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Comprehensive Antiretroviral Table: Adult Dosing, Dosage Form Modifications, Adverse Reactions and Interaction Potential

Source: nccc.ucsf.edu
Clinical Resource: Table
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Last Checked: 25/04/16 Link Error: Report It

 

Helpful HIV Medication Tables for Pharmacists

This guide tailored for pharmacists summarizes HIV medications dosing, patient counseling points, and concurrent medication to avoid.

Source: nynjaetc.org
Clinical Resource: Guide
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Last Checked: 20/05/14 Link Error: Report It

 

HIV Medication Guide
Antiretroviral charts of HIV drug interactions

Select Drug To View Direct Interaction

Source: hivmedicationguide.com
Clinical Resource: Database
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Last Checked: 22/01/13 Link Error: Report It

 

Drug Interaction Tables

Antiretroviral Interactions
Interactions with Other Drug Classes

Source: hivclinic.ca
Clinical Resource: Tables
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Last Checked: 15/12/14 Link Error: Report It

 

Drug Interactions

Commonly found drug interactions with antiretroviral agents.

Source: washington.edu
Clinical Resource: Charts
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Last Checked: 05/01/15 Link Error: Report It

 

EDL (Essential Drugs List) - Antiretrovirals Interactions Table

This table has been compiled to reduce the occurrence of clinically relevant drug-drug interactions between the antiretrovirals available in the public sector and most medicines listed on the Essential Drugs List.

Produced by: National HIV HCW Hotline, Medicines Information Centre, Division of Clinical Pharmacology, Faculty of Health Sciences, University of Cape Town

Source: mic.uct.ac.za
Clinical Resource: Booklet
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HIV and HCV Drug Interactions: A Quick Guide for Clinicians

HCV guidelines including specific information for treating patients with HIV/HCV co-infection HCV (NS5b polymerase inhibitor & NS3/4A protease inhibitor included)

Source: nynjaetc.org
Clinical Resource: Table
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Recreational Drugs and HIV Antiretrovirals: A Guide to Interactions for Clinicians

This educational guide is intended to provide advice that may reduce harm to patients who use substances such as the drugs cocaine, LSD, Marijuana, etc. and there effects on the human mind and body

Source: nynjaetc.org
Clinical Resource: Guide
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Last Checked: 20/05/14 Link Error: Report It

 

HEP Drug Interactions
University of Liverpool

This web site was established in 2010 by members of the Department of Pharmacology at the University of Liverpool to offer a resource for healthcare providers, researchers and patients to be able to understand and manage drug-drug interactions.

Source: hep-druginteractions.org
Clinical Resource: Various
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Warfarin, antiplatelet drugs and their interactions

Patients who are being treated with warfarin may sometimes be prescribed or buy antiplatelet drugs, such as aspirin. As warfarin and antiplatelet drugs increase the risk of bleeding, their combination can put patients at risk of a major haemorrhage. This risk may be further increased by the patient's age and other illnesses.

Source: nps.org.au
Clinical Resource: Journal Article
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Warfarin Drug Interactions

The drugs in this list are more usually associated with loss of INR control in patients already established on warfarin.

Source: derbyhospitals.nhs.uk
Clinical Resource: List
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Last Checked: 02/07/14 Link Error: Report It

 

Clopidogrel and Possible Interaction with Proton Pump Inhibitors

The interaction between clopidogrel and PPIs has been examined recently in systematic reviews and metaanalyses. In general, the studies included in these reviews, investigate the effects of PPIs as a class on the incidence on major adverse cardiac events in patients who are treated with clopidogrel and include patients taking any PPI.

Source: ggcprescribing.org.uk
Clinical Resource: Bulletin
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Last Checked: 22/04/13 Link Error: Report It

 

European Society of Hypertension Newsletter
Interactions Between Antihypertensive Agents and Other Drugs

Source: eshonline.org
Clinical Resource: Newsletter
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Last Checked: 19/08/15 Link Error: Report It

 

Drug interactions with statins

This bulletin summarises important interactions with the three currently funded statins in New Zealand: simvastatin, atorvastatin and pravastatin.

Source: druginformation.co.nz
Clinical Resource: Drug Information Service Bulletin
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Last Checked: 19/10/15 Link Error: Report It

 

AED-AED interactions

Common AED/Non-AED interactions

Interactions: Antidepressants and Antiepileptic Drugs

Major Antimicrobial-Anticonvulsant Interactions

Source: epilepsy.com
Clinical Resource: Tables
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Last Checked: 08/04/14 Link Error: Report It

 

Clinically relevant drug interactions with antiepileptic drugs

Comprehensive reviews of interactions involving AEDs have been published recently. The purpose of the present review is to highlight those which, because of their frequency or magnitude, are especially likely to have adverse clinical consequences.

Source: eu.wiley.com
Clinical Resource: Journal Article
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Last Checked: 16/05/13 Link Error: Report It

 

The clinical relevance of pharmacokinetics and drug interactions with anti epileptic drugs

In this paper an overview will be given of how knowledge of pharmacokinetic mechanisms determines which pharmacokinetic characteristics an AED should have. Various clinical factors such as age, underlying physiological conditions and drug interactions will also affect the pharmacokinetics and efficacy of AED medication. It will be shown how by anticipating changes in pharmacokinetics due to possible drug interactions, or alterations in one of the pharmacokinetic parameters, adverse effects and breakthrough seizures may be averted and aid in the choice of optimal AED therapy for each patient.

Source: mcppnet.org
Clinical Resource: Journal Article
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Last Checked: 17/02/14 Link Error: Report It

 

Faculty of Sexual and Reproductive Healthcare Clinical Effectiveness Unit Statement
Antiepileptic Drugs and Contraception

Source: fsrh.org
Clinical Resource: Statement
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Last Checked: 10/06/15 Link Error: Report It

 

 

Evidence-based guideline: Antiepileptic drug selection for people with HIV/AIDS

Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Ad Hoc Task Force of the Commission on Therapeutic Strategies of the International League Against Epilepsy

Source: aesnet.org
Clinical Resource: Guideline
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Last Checked: 20/05/14 Link Error: Report It

 

Clinical Significance of Pharmacokinetic Interactions Between Antiepileptic and Psychotropic Drugs

The purpose of this article is to provide a concise overview of pharmacokinetic interactions between psychotropic agents and antiepileptic drugs (AEDs).

Source: eu.wiley.com
Clinical Resource: Journal Article
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Last Checked: 17/02/14 Link Error: Report It

 

Drug-Drug Interactions

Examine potential interactions of pain medications

Source: painedu.org
Clinical Resource: Tool
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Last Checked: 23/07/13 Link Error: Report It

 

Opioid Drug-Drug Interactions

Source: paineducation.vcu.edu
Clinical Resource: Table
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Last Checked: 24/04/14 Link Error: Report It

 

Methadone-Drug Interactions (Medications, illicit drugs, & other substances)

Section Contents

Understanding Methadone Metabolism & Drug Interactions
Table 1: Drugs That Are Contraindicated with Methadone (May Precipitate Opioid Withdrawal)
Table 2: Drugs That May Result in Altered Metabolism or Unpredictable Interactions with Methadone
Table 3: Drugs That May Lower SML and/or Decrease Methadone Effects
Table 4: Drugs That May Raise SML and/or Increase Methadone Effects
Table 5: Methadone-Drug Interactions: Alphabetical Listing by Generic & Brand Names

Source: atforum.com
Clinical Resource: Document
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Faculty of Sexual and Reproductive Healthcare Clinical Guidance
Drug Interactions with Hormonal Contraception

Source: fsrh.org
Clinical Resource: Guidance
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Last Checked: 10/06/15 Link Error: Report It

 

Drug interactions and hormonal contraception

Drug interactions with contraceptives are of concern, particularly when steroid metabolism is induced, as this may reduce contraceptive efficacy. The author discusses the prediction of drug interactions and the interpretation of pharmacokinetic interaction studies of combined hormonal contraceptives.

Source: eu.wiley.com
Clinical Resource: Journal Article
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Last Checked: 18/06/13 Link Error: Report It

 

Do antibiotics interfere with the efficacy of oral contraceptives?

Among antibiotics, only rifampin has been demonstrated to interfere with the effectiveness of oral contraceptives (OCs) (strength of recommendation [SOR]: C, limited case series).

Source: jfponline.com
Clinical Resource: Evidence Based Answer to Clinical Question
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Last Checked: 29/10/13 Link Error: Report It

 

Faculty of Sexual and Reproductive Healthcare
Statement on Drug Interactions between Hormonal Contraception and Ulipristal Products: ellaOne® and Esmya®

Source: fsrh.org
Clinical Resource: Statement
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Last Checked: 10/06/15 Link Error: Report It

 

Drug interactions with methotrexate

Methotrexate (MTX) is an antimetabolite cytotoxic drug with immunosuppressant properties. It is used in high doses (>1g/m2 of body surface area) to treat malignant neoplasms, and in low doses (<25mg) in the treatment of psoriasis and rheumatoid arthritis. This bulletin aims to provide an overview of some clinically significant drug interactions of MTX.

Source: druginformation.co.nz
Clinical Resource: Drug Information Service Bulletin
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Last Checked: 19/07/13 Link Error: Report It

 

Summary of some common drug interactions seen in Aged Care Homes

Source: nevdgp.org.au
Clinical Resource: Summary
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Last Checked: 23/07/13 Link Error: Report It

 

Drug Interactions in Palliative Care

Advanced cancer patients are at risk of potential drug interactions because they are often on many medications. Drug-drug interactions can be kinetic, dynamic and pharmaceutical. Pharmacokinetic interactions mainly involved Cytochrome P450 enzymes system.

Source: fmshk.org
Clinical Resource: Newsletter
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Last Checked: 24/04/14 Link Error: Report It

 

Undesirable drug interaction in palliative medicine

The importance of drug interactions in palliative care is acquiring more and more practical importance. In the polytherapy used in palliative care, drugs can induce a number of interactions and increase the risk of unwanted drug reactions. This paper discusses the importance of drug-drug interactions in clinical practice.

Source: czasopisma.viamedica.pl
Clinical Resource: Journal Article
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Last Checked: 24/04/14 Link Error: Report It

 

Drug Interactions in Dermatology

This article aims to assist pharmacists in identifying patients at risk for clinically significant dermatologic drug interactions, review the general mechanisms of drug interactions, and help lower patients' risk with a discussion of select dermatologic drugs that may lead to adverse effects. With this knowledge, as well as proper screening, prescribing, and monitoring, clinicians can help prevent fatal consequences.

Source: uspharmacist.com
Clinical Resource: Journal Article
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Last Checked: 13/05/14 Link Error: Report It

 

Drug Interactions with Tobacco Smoke

Many interactions between tobacco smoke and medications have been identified. Note that in most cases it is the tobacco smoke—not the nicotine—that causes these drug interactions. Tobacco smoke interacts with medications through pharmacokinetic (PK) and pharmacodynamic (PD) mechanisms. PK interactions affect the absorption, distribution, metabolism, or elimination of other drugs, potentially causing an altered pharmacologic response.

Source: smokingcessationleadership.ucsf.edu
Clinical Resource: Table
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Last Checked: 20/08/15 Link Error: Report It

 

Potential drug interactions with smoking and quitting

Chart of the most common drug interaction issues connected to the use of tobacco

Source: health.gov.bc.ca
Clinical Resource: Chart
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Last Checked: 08/07/13 Link Error: Report It

 

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