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Stability of Drugs in Compliance Aids

Welcome to the stability of drugs in compliance aids section for pharmacists. This section includes links to drug information resources on light sensitive drugs and what medicines can be repackaged in compliance aids / dose administration aids (DAA) / monitored dosage systems (MDS).

Stability of Drugs in Compliance Aids
Prepared and updated by Medicines Information, Pharmacy Department, Pinderfields General Hospital

The tabulated guide is self-explanatory. It is an alphabetical list of drugs sorted by generic name. Defined against each drug name are the Trade Name, Source of information (usually the manufacturer) and the Date on which the information was last reviewed.

Under the heading "Stability", information has been tabulated in two columns. The first column refers to information received from the manufacturer and the second column refers to local practice at Pinderfields General Hospital.

Source: webarchive.org.uk
Clinical Resource: Guide
Register to Access Content: No

Last Checked: 11/11/16 Link Error: Report It

 

UKMI (UK Medicines Information) Medicines Compliance Aid Stability

What UKMI MCA stability information does – it makes recommendations on the suitability of solid dose forms for transfer from the manufacturers’ original packaging to multi-compartment compliance aids (MCAs). These recommendations are based on

  • physico-chemical stability and characteristics of the medicine and its formulation(s).
  • advice, where available, from manufacturers
  • data, where available, on storage in MCAs
Source: sps.nhs.uk
Clinical Resource: Database
Register to Access Content: No

Last Checked: 11/11/16 Link Error: Report It

 

Monitored Dosage System - Drug Exclusion List
Leicestershire Medicines Strategy Group

Drugs not to be put in compliance aids

Using the information obtained, more general guidelines for the transfer of solid oral dosage forms from original packs to compliance aids have been written.

Source: lmsg.nhs.uk
Clinical Resource: Guideline
Register to Access Content: No

Last Checked: 11/11/16 Link Error: Report It

 

Dose Administration Aids Service - Guidelines and Standards for Pharmacists
Pharmaceutical Society of Australia

Appendix 5: Examples of medicines which should not be packed in DA

Source: psa.org.au
Clinical Resource: Guideline
Register to Access Content: No

Last Checked: 11/11/16 Link Error: Report It

 

Effectiveness and cost effectiveness of Dose Administration Aids
Project conducted by Quality Medication Care Pty Ltd in conjunction with the Therapeutics Research Unit, University of Queensland, Princess Alexandra Hospital

Many consumers are taking a number of medications at once (often between 8 and 24) and frequently may need to take these medicines at different times during the day. Dosage administration aids (DAAs) are designed to improve the adherence (or compliance) of consumers by clearly setting out the medicine doses in separate compartments, ensuring the correct medication is taken in the correct dose and at the appropriate time.

Source: guild.org.au
Clinical Resource: Report
Register to Access Content: No

Last Checked: 11/11/16 Link Error: Report It

 

How stable are medicines moved from original packs into compliance aids?

In this article, Claire Church and Jane Smith have compiled a table based on information received from manufacturers about the possible stability of their medicines after removal from their packaging and placement in compliance aids

Source: pharmaceutical-journal.com
Clinical Resource: Journal Article
Register to Access Content: Yes - content available to members of the RPS and paid subscribers

Last Checked: 11/11/16 Link Error: Report It

 

Evidence of Stability of Medicines Repackaged in Compliance Aids: A Review

This paper presents a comprehensive review and detailed discussion of the available literature on the stability implications of repackaging medicines into compliance aids. The importance of repackaging is thus highlighted by its ability to impact on therapeutic outcomes for patients.

Source: benthamscience.com
Clinical Resource: Journal Article
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Last Checked: 11/11/16 Link Error: Report It

 

Compliance Aids and Medicine Stability: New Evidence of Quality Assurance

This review presents clinical evidence for repackaging into Dose Administration Aids (DAAs), the Australian Pharmaceutical Advisory Committee and other guidelines on general stability issues related to repackaging and a summary of evidence for stability studies conducted in the practice.

Source: benthamscience.com
Clinical Resource: Journal Article
Register to Access Content: No

Last Checked: 11/11/16 Link Error: Report It

 

Dose administration aids: Pharmacists’ role in improving patient care

Drug manufacturers, on the whole, tend to discourage repackaging of medications and there is little quality data available to support this process. Indeed, only a small number of medications have been investigated for their stability following repackaging into DAAs, namely atenolol, paracetamol, frusemide, prochlorperazine, sodium valproate, aspirin (dosette boxes) and clozapine. This paper will review the repackaging of medications into DAAs and the role that the pharmacist plays in this process to improve patient care, in addition to presenting the Australian research that has contributed substantially to the body of information available internationally on the quality implications, relating to the stability of medicines repackaged into DAAs.

Source: amj.net.au
Clinical Resource: Journal Article
Register to Access Content: No

Last Checked: 11/11/16 Link Error: Report It

 

Monitored Dosage Systems (MDS) Guidance for Health & Social Care Professionals in Herefordshire
NHS Herefordshire

This guidance has been drawn up in order to facilitate a consistent approach across Herefordshire for referrals to pharmacists to ensure that limited resources available to pharmacists in re-packaging medicines are secured for those patients most likely to benefit.

Source: herefordshireccg.nhs.uk
Clinical Resource: Guidance
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Last Checked: 11/11/16 Link Error: Report It

 

Many Common Drugs in Dermatology are Light, Temperature, or Moisture-Sensitive

Photosensitivity is defined as responsiveness to light exposure. For many common dermatologic drugs, proper storage conditions are essential for maintaining drug activity. Degradation and loss of activity can occur with exposure to light, temperature, and/ or moisture. For example, ketoconazole degrades after 24 hours of light exposure. In this article storage guidelines for common dermatology drugs are provided. We suspect that drug degradation is common due to improper storage and that improved patient instruction regarding storage will reduce degradation and alleviate some of the danger associated with improper storage and usage patterns.

Source: skintherapyletter.com
Clinical Resource: Article
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Last Checked: 11/11/16 Link Error: Report It

 

Light-Sensitive Oral Prescription Drugs

After receiving such a question in our Drug Information Center, it became apparent that there was a lack of resources available for an overall list and, after exploring several outlets(PubMed, Facts & Comparisons 4.0, and several listserves), we were able to locate 1 list published in 2008. It seems as if the authors of this list experienced the same conundrum as us. Thus, we expanded and updated the list to provide the following compilation of light-sensitive medications.

Source: thomasland.com
Clinical Resource: Journal Article
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Last Checked: 11/11/16 Link Error: Report It

 

Stability Implications of Repackaging Paracetamol Tablets into Dose Administration Aids

Despite the widespread use of dose administration aids (DAAs) there is little available data on the stability of drugs during repackaging or storage in these devices.

Source: griffith.edu.au
Clinical Resource: Journal Article
Register to Access Content: No

Last Checked: 11/11/16 Link Error: Report It

 

Pilot study of the short-term physico-chemical stability of atenolol tablets stored in a multi-compartment compliance aid

Very little is known about the stability of solid-dose medicines taken out of their sealed, manufacturers’ packs and placed together, or even singly, within MCCAs, because manufacturers usually test the stability of their products in the final packaging.

Source: eahp.eu
Clinical Resource: Journal Article
Register to Access Content: No

Last Checked: 11/11/16 Link Error: Report It

 

Stability of Frusemide Tablets Repackaged in Dose Administration Aid

Repackaging tablets into a dose administration aid (DAA) requires that the pharmacist consider the stability of the active pharmaceutical ingredient and the excipients of the drug product. Frusemide is susceptible to photodegradation and is commonly repackaged into DAAs.

Source: griffith.edu.au
Clinical Resource: Journal Article
Register to Access Content: No

Last Checked: 11/11/16 Link Error: Report It

 

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