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Haematology / Hematology

Welcome to the haematology / hematology category for physicians and pharmacists. This category features links to prescribing and clinical practice resources on anticoagulants, parenteral iron preparations, guidelines on haematological diseases and more.

British Committee for Standards in Haematology Guidelines

Source: b-s-h.org.uk
Clinical Resource: Guidelines
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Last Checked: 16/11/16 Link Error: Report It

 

American Society of Hematology Clinical Guidelines

Source: hematology.org
Clinical Resource: Guidelines
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Last Checked: 20/08/15 Link Error: Report It

 

American Society of Hematology Quick-Reference Guides

ASH has developed the following clinical quick-reference guides to help physicians provide quality care to patients.

Source: hematology.org
Clinical Resource: Reference Guides
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Last Checked: 23/10/15 Link Error: Report It

 

Common Haematology Reference Ranges

Source: ldhpathology.co.uk
Clinical Resource: Table
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Last Checked: 02/07/14 Link Error: Report It

 

The Cochrane Collaboration
Cochrane Reviews - Blood Disorders

Cochrane is an international, non-profit, independent organisation, established to ensure that up-to-date, accurate information about the effects of healthcare interventions is readily available worldwide. It produces and disseminates systematic reviews of healthcare interventions, and promotes the search for evidence in the form of clinical trials and other studies of the effects of interventions.

Source: cochrane.org
Clinical Resource: Systematic Reviews
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Last Checked: 13/07/15 Link Error: Report It

 

Bloody Easy for Healthcare Professionals

Bloody Easy 3: Blood Transfusions, Blood Alternatives and Transfusion Reactions. A Guide to Transfusion Medicine Third Edition
Bloody Easy Coagulation Simplified

Source: transfusionontario.org
Clinical Resource: Publications
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Last Checked: 02/07/14 Link Error: Report It

 

Thrombosis Canada Clinical Guides

The Thrombosis Canada™ Clinical Guides are:

  • Developed by Thrombosis Canada™ members, internationally recognized as experts
  • Reflect recommendations of evidence based clinical practice guidelines
  • Designed to be robust, yet concise enough to be applicable at the point of care
Source: thrombosiscanada.ca
Clinical Resource: Guides
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Last Checked: 02/07/14 Link Error: Report It

 

National Institute for Health and Care Excellence (NICE) Guidance > Embolism and thrombosis

Source: nice.org.uk
Clinical Resource: Guidance
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Last Checked: 10/11/17 Link Error: Report It

 

Scottish Intercollegiate Guidelines Network (SIGN) Guideline > Prevention and Management of Venous Thromboembolism

Source: sign.ac.uk
Clinical Resource: Guideline
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Last Checked: 28/09/17 Link Error: Report It

 

European Society of Cardiology Guidelines on the Diagnosis and Management of Acute Pulmonary Embolism

Source: escardio.org
Clinical Resource: Guideline
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Last Checked: 08/06/15 Link Error: Report It

 

Royal College of Obstetricians and Gynaecologists Guideline on Reducing the Risk of Venous Thromboembolism during Pregnancy and the Puerperium

Source: rcog.org.uk
Clinical Resource: Guideline
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Last Checked: 19/08/15 Link Error: Report It

 

Royal College of Obstetricians and Gynaecologists Guideline on Thromboembolic Disease in Pregnancy and the Puerperium: Acute Management

Source: rcog.org.uk
Clinical Resource: Guideline
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Last Checked: 19/08/15 Link Error: Report It

 

Venous Thromboembolism (VTE) and Hormonal Contraception
Faculty of Sexual & Reproductive Healthcare Statement

Source: fsrh.org
Clinical Resource: Statement
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Last Checked: 10/06/15 Link Error: Report It

 

Risk of venous thromboembolism in users of non-oral contraceptives
Statement from the Faculty of Sexual & Reproductive Healthcare

Source: fsrh.org
Clinical Resource: Statement
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Last Checked: 10/06/15 Link Error: Report It

 

Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines

Source: chestnet.org
Clinical Resource: Guideline
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Last Checked: 02/07/14 Link Error: Report It

 

Scottish Intercollegiate Guidelines Network (SIGN) Guideline > Antithrombotics: Indications and Management

Source: sign.ac.uk
Clinical Resource: Guideline
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Last Checked: 28/09/17 Link Error: Report It

 

BestBETs
Thromboembolic disease

BETs were developed in the Emergency Department of Manchester Royal Infirmary, UK, to provide rapid evidence-based answers to real-life clinical questions, using a systematic approach to reviewing the literature. BETs take into account the shortcomings of much current evidence, allowing physicians to make the best of what there is.

Source: bestbets.org
Clinical Resource: Evidence Based Answers to Clinical Questions
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Last Checked: 02/07/14 Link Error: Report It

 

e-VTE
A web based education resource designed to help raise awareness and improve understanding of Venous Thromboembolism

The e-learning session for healthcare professionals in Secondary Care first published in 2010 and updated in 2013 is aimed at nurses, pharmacists and junior doctors to help them understand the concept of hospital-associated thrombosis and how to prevent it.

Source: e-lfh.org.uk
Clinical Resource: CE / CPD / Learning
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Last Checked: 19/08/15 Link Error: Report It

 

Lifeblood: The Thrombosis Charity
Professional Section

The professional section offers healthcare professionals an extensive resource to stay up to date with the latest developments in the diagnosis and management of venous thromboembolism.

Professional

  • Hospital-Based Health Professionals
  • GP's and Community Healthcare Professionals
Source: thrombosis-charity.org.uk
Clinical Resource: Various
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Last Checked: 02/07/14 Link Error: Report It

 

Best Practices Preventing Deep Vein Thrombosis and Pulmonary Embolism

For over a decade, we have been involved in projects to improve the use of prophylaxis for deep vein thrombosis (DVT) in Massachusetts hospitals. We want to share the lessons of this experience. The tools provided in this manual will help you to create a structured quality improvement program that can assist physicians and hospital quality assurance managers in evaluating and improving the use of DVT prophylaxis. Implementation of a system-wide process for preventing DVT will also help your hospital meet the JCAHO requirement for quality improvement activities.

Source: outcomes-umassmed.org
Clinical Resource: Various
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Last Checked: 02/07/14 Link Error: Report It

 

Management of venous thrombosis in pregnancy

The management of venous thromboembolism in pregnancy is challenging, as many diagnostic tests are less accurate in pregnant than in non-pregnant patients, and some of the radiological procedures are potentially hazardous to the fetus. In addition, anticoagulant treatment with coumarins can cause embryopathy. The authors recommend strategies for women at risk of deep venous thrombosis or pulmonary thromboembolism during pregnancy and outline appropriate investigations and treatment.

Source: eu.wiley.com
Clinical Resource: Journal Article
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Last Checked: 07/05/14 Link Error: Report It

 

Pulmonary embolism

This article reviews the epidemiology, clinical features, diagnostic process, and treatment of pulmonary embolism.

Source: racgp.org.au
Clinical Resource: Journal Article
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Last Checked: 02/07/14 Link Error: Report It

 

Diagnosing pulmonary embolism

Objective testing for pulmonary embolism is necessary, because clinical assessment alone is unreliable and the consequences of misdiagnosis are serious. No single test has ideal properties (100% sensitivity and specificity, no risk, low cost).

Source: europepmc.org
Clinical Resource: Journal Article
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Last Checked: 07/04/14 Link Error: Report It

 

Using low molecular weight heparin

This bulletin looks at the appropriate prescribing and monitoring of LMWH for the treatment and prophylaxis of VTE in adults.

Source: wemerec.org
Clinical Resource: Medicines Resource Centre Bulletin
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Last Checked: 16/11/17 Link Error: Report It

 

Laboratory Monitoring of Low Molecular Weight Heparins

Routine laboratory monitoring is not routinely required, with the exception of patients with renal insuffciency. However, since LMWHs inhibit factor Xa more than thrombin, assays for anti-factor Xa activity, rather than the aPTT, must be used for monitoring.

Source: pathology.vcu.edu
Clinical Resource: Educational Resource
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Last Checked: 17/02/14 Link Error: Report It

 

Enoxaparin in patients with severe renal impairment

There have been a number of medication incidents reported recently involving the use of enoxaparin in patients with severe renal impairment (creatinine clearance less than 30ml/min) who, as a result of treatment have suffered a haemorrhage.

Source: medicinesgovernance.hscni.net
Clinical Resource: Memo
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Last Checked: 31/03/14 Link Error: Report It

 

Laboratory Monitoring of Unfractionated Heparin

Heparin therapy requires rigorous laboratory monitoring with the activated partial thromboplastim time (aPPT), since its bioavailability is variably affected by binding to plasma and cellular proteins. Unfractionated heparin is gradually being replaced by low molecular weight heparin, which has a longer half-life and more predictable bioavailability.

Source: pathology.vcu.edu
Clinical Resource: Educational Resource
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Last Checked: 17/02/14 Link Error: Report It

 

WarfarinDosing.org

Welcome to WarfarinDosing.org, a free Web site to help doctors and other clinicians begin warfarin therapy by estimating the therapeutic dose in patients new to warfarin. This site is supported by the Barnes-Jewish Hospital at Washington University Medical Center, the NIH, and donations. Estimates are based on clinical factors and (when available) genotypes of two genes: cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1).

Recommendations on this Web site are based on data from over 1000 patients.Once information is entered onto the next page, the initial estimate of therapeutic dose explains 53% of the variability in a warfarin dose. If you return to the Web site and enter an INR value after 3 and/or 4 warfarin doses, the dose refinement is even more accurate.

Source: warfarindosing.org
Clinical Resource: Calculator
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Last Checked: 17/02/14 Link Error: Report It

 

Laboratory Monitoring of Warfarin Therapy

Crystalline warfarin sodium (Coumadin, Panwarfin, Sofarin, Coufarin, Athrombin-K) is the most widely used oral anticoagulant in the world. Warfarin interferes with the hepatic synthesis of the vitamin-K dependent coagulation factors by interfering with the vitamin K cycle. Laboratory monitoring of warfarin therapy is mandatory, since the agent has a relatively narrow therapeutic range.

Source: pathology.vcu.edu
Clinical Resource: Educational Resource
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Last Checked: 17/02/14 Link Error: Report It

 

Management of Warfarin Overdose and Supratherapeutic INR

Full reversal of warfarin-induced coagulopathy is indicated in patients who do not require warfarin therapy. However, special consideration must be given to patients who require therapeutic anticoagulation in the event of a warfarin overdose. The purpose of this discussion is to review treatment guidelines for these patents.

Source: utah.edu
Clinical Resource: Poison Control Centre Newsletter
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Last Checked: 02/07/14 Link Error: Report It

 

Warfarin Drug Interactions

The drugs in this list are more usually associated with loss of INR control in patients already established on warfarin.

Source: derbyhospitals.nhs.uk
Clinical Resource: List
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Last Checked: 02/07/14 Link Error: Report It

 

Anticoagulants and pregnancy: When are they safe?

While anticoagulants are useful in many circumstances, their use during pregnancy increases the risk of hemorrhage and other adverse effects on the mother and the fetus. Treatment with anticoagulants during pregnancy must therefore be carefully considered, with judicious selection of the agent, and with reflection on the physiologic changes of pregnancy to ensure appropriate dosing. In this article, we review these issues.

Source: mdedge.com
Clinical Resource: Journal Article
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Last Checked: 19/06/17 Link Error: Report It

 

Can small volume intramuscular injections be given to patients taking oral anticoagulants?
Prepared by UK Medicines Information (UKMi) pharmacists for NHS healthcare professionals

This Medicines Q&A focuses on the potential risks of adverse effects associated with the administration of small volume IM injections to patients taking oral anticoagulants.

Source: evidence.nhs.uk
Clinical Resource: Medicines Question and Answer
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Last Checked: 21/02/14 Link Error: Report It

 

British Society of Gastroenterology Clinical Guideline for the Management of Anticoagulant and Antiplatelet Therapy in Patients Undergoing Endoscopic Procedures

Source: bsg.org.uk
Clinical Resource: Guideline
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Last Checked: 13/03/14 Link Error: Report It

 

Management of antithrombotic agents for endoscopic procedures

The Standards of Practice Committee of the American Society for Gastrointestinal Endoscopy prepared this text.

Source: asge.org
Clinical Resource: Guideline
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Last Checked: 02/07/14 Link Error: Report It

 

Handbook of Transfusion Medicine
United Kingdom Blood Services 5th edition

The purpose of this handbook is to help the many staff involved in providing and using blood products to make sure that the right blood product is given to the right patient at the right time.

Source: transfusionguidelines.org.uk
Clinical Resource: Handbook
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Last Checked: 07/04/14 Link Error: Report It

 

Risks from, and appropriate use of, blood products

. This article aims to inform clinicians how to avoid these risks and how to make appropriate use of blood products.

Source: rcpe.ac.uk
Clinical Resource: Journal Article
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Last Checked: 02/07/14 Link Error: Report It

 

Blood Conservation and Transfusion Avoidance Strategies in the Surgical Patient

These guidelines were prepared by the Department of Surgical Education, Orlando Regional Medical Center

Source: surgicalcriticalcare.net
Clinical Resource: Guideline
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Last Checked: 21/08/15 Link Error: Report It

 

Care pathways for the management of adult patients refusing blood (including Jehovah s Witness patients)

These draft care pathways have been developed on behalf of the London Regional Transfusion Committee with the aim of promoting a more standardised approach to the management of adult surgical patients refusing blood/blood component therapy (including JW patients).

Source: transfusionguidelines.org.uk
Clinical Resource: Care Pathways
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Last Checked: 07/04/14 Link Error: Report It

 

Iron Therapy.org

The refreshed irontherapy.org website is a non-promotional, educational online resource which offers healthcare professionals, from a host of different therapeutic areas, the current and topical information they need to understand and manage iron deficiency effectively.

The development of the site content is guided and overseen by the Iron Therapy Steering Committee; a group of respected experts in iron therapy who play an integral role in the management and growth of the website. By submitting opinion pieces and participating in interviews and advisory boards, the Steering Committee influence the evolution of the site through strategic planning – and work with the Iron Therapy Secretariat to define editorial policy and content.

Source: irontherapy.org
Clinical Resource: Various
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Last Checked: 02/07/14 Link Error: Report It

 

British Society of Gastroenterology Guidelines for the Management of Iron Deficiency Anaemia

Source: bsg.org.uk
Clinical Resource: Guideline
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Last Checked: 02/07/14 Link Error: Report It

 

British Columbia Clinical Practice Guideline for Iron Deficiency - Investigation and Management

Source: gov.bc.ca
Clinical Resource: Guideline
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Last Checked: 19/08/15 Link Error: Report It

 

CosmoFer®
Healthcare Professionals

CosmoFer.com offers information about iron deficiency anaemia and parenteral iron therapy.

Source: cosmofer.com
Clinical Resource: Various
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Last Checked: 22/02/17 Link Error: Report It

 

Aintree University Hospitals NHS
Guidelines for prescription and administration of intravenous Iron Sucrose

Source: aintreerenalunit.nhs.uk/aintreerenal
Clinical Resource: Guideline
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Last Checked: 22/02/17 Link Error: Report It

 

How do I use CosmoFer® (iron dextran) total dose infusion for correction of iron deficiency anaemia?
Prepared by UK Medicines Information (UKMi) pharmacists for NHS healthcare professionals

The dose and dosage schedule for CosmoFer® must be determined individually based on a calculation of the patients total iron deficit; the total cumulative dose is determined by the patients haemoglobin (Hb) concentration (in g/dL) and their body weight (in kg).

Source: sps.nhs.uk
Clinical Resource: Medicines Question and Answer
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Last Checked: 22/09/16 Link Error: Report It

 

Iron Dextran Dosing calculator (iron deficit)

Source: globalrph.com
Clinical Resource: Calculator
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Last Checked: 02/07/14 Link Error: Report It

 

Parenteral iron preparations and iron deficiency anaemia

Source: auspharmlist.net.au
Clinical Resource: Pharmacy E-Bulletin
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Last Checked: 22/02/17 Link Error: Report It

 

British Columbia Clinical Practice Guideline on Cobalamin (vitamin B12) Deficiency - Investigation & Management

Source: gov.bc.ca
Clinical Resource: Guideline
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Last Checked: 19/08/15 Link Error: Report It

 

British Columbia Clinical Practice Guideline on Folate Deficiency - Investigation & Management

Source: gov.bc.ca
Clinical Resource: Guideline
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Last Checked: 19/08/15 Link Error: Report It

 

National Institute for Health and Care Excellence (NICE) Guidance > Chronic kidney disease: managing anaemia

Source: nice.org.uk
Clinical Resource: Guidance
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Last Checked: 10/11/17 Link Error: Report It

 

Anaemia management in patients with chronic kidney disease: a position statement by the Anaemia Working Group of European Renal Best Practice (ERBP)

Source: european-renal-best-practice.org
Clinical Resource: Position Statement
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Last Checked: 02/07/14 Link Error: Report It

 

G6PD Deficiency Association - favism

The association offers assistance to persons affected by the G6PD enzyme deficiency and their families, including helping with the protection of patients' social rights; informing and educating affected persons and the medical community on all aspects of the deficiency; helping organize petitions calling for government actions; and more.

Among the resources offered by the association are lists of contraindicated drugs (including some trade-names); an online forum; mailing lists; and a reserved area for medical professionals.

Source: g6pd.org
Clinical Resource: Various
Register to Access Content: Yes - registration is FREE

Last Checked: 02/07/14 Link Error: Report It

 

Glucose-6-phosphate dehyrogenase deficiency

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common inherited enzyme deficiency that affects red blood cells (RBCs). It is highly prevalent in Africa, Asia, Oceania and Southern Europe, but can occur rarely in other individuals.

Source: auspharmlist.net.au
Clinical Resource: Pharmacy E-Bulletin
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Last Checked: 02/07/14 Link Error: Report It

 

International Association of Sickle Cell Nurses and Physician Assistants Clinical Practice Guidelines

Source: iascnapa.org
Clinical Resource: Guidelines
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Last Checked: 02/07/14 Link Error: Report It

 

National Institute for Health and Care Excellence (NICE) Guidance > Sickle cell disease: managing acute painful episodes in hospital

Source: nice.org.uk
Clinical Resource: Guidance
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Last Checked: 10/11/17 Link Error: Report It

 

Sickle Cell Information Center

The mission of this site is to provide sickle cell patient and professional education, news, research updates and world wide sickle cell resources.

Source: scinfo.org
Clinical Resource: Various
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Last Checked: 02/07/14 Link Error: Report It

 

Sickle Cell

Key Inforbits

  • Sickle cell disease pathology
  • Risk factors for complicated disease
  • Screening and diagnosis
  • Treatment
  • Prevention of complications
  • Did you know?
Source: auburn.edu
Clinical Resource: Drug Information and Learning Resources Centre Bulletin
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Last Checked: 19/08/15 Link Error: Report It

 

Thalassaemia International Federation Publications

Thalassaemia International Federation has a plethora of educational publications that provide concise, up-to date information on all aspects of thalassaemia, from prevention to clinical management, and cover almost all age groups.

TIF’s publications have been translated into many languages, in order to cover the needs of the medical/scientific community, the thalassaemia patients’/parents’ community and the general public.

Source: thalassaemia.org.cy
Clinical Resource: Publications
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Last Checked: 02/07/14 Link Error: Report It

 

Routine investigations in the management of thalassaemia

All thalassaemia patients (children and adults) should be assessed at least once a year at a specialist thalassaemia centre by a paediatrician or haematologist experienced in the treatment of thalassaemia. This is intended to give a detailed assessment of every aspect of the patient’s treatment and condition; to assess the patient’s progress and identify any areas where treatment could be improved. Additional investigations and measurements should be kept between the annual review checks, and recorded and discussed.

Source: ukts.org
Clinical Resource:
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Last Checked: 02/07/14 Link Error: Report It

 

Guidelines for malaria prevention in travellers from the UK

These practical guidelines from the Public Health England Advisory Committee on Malaria Prevention for UK Travellers are updated and reissued annually. They are for use by healthcare workers who advise travellers but may also be of use to prospective travellers who wish to read about the options themselves.

Source: gov.uk
Clinical Resource: Guideline
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Last Checked: 29/09/15 Link Error: Report It

 

Royal College of Obstetricians and Gynaecologists Guideline on the Prevention of Malaria in Pregnancy

Source: rcog.org.uk
Clinical Resource: Guideline
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Last Checked: 19/08/15 Link Error: Report It

 

UK malaria treatment guidelines > Page 117 - Pregnant women
British Infection Society

This document offers guidance for the management of both uncomplicated and complicated malaria in the UK.

Source: britishinfection.org
Clinical Resource: Guideline
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Last Checked: 20/08/15 Link Error: Report It

 

Royal College of Obstetricians and Gynaecologists Guideline on the Diagnosis and Treatment of Malaria in Pregnancy

Source: rcog.org.uk
Clinical Resource: Guideline
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Last Checked: 19/08/15 Link Error: Report It

 

Centers for Disease Control and Prevention
Malaria

Malaria Topics

About Malaria
Diagnosis & Treatment
Malaria Worldwide
Travelers
Tools for Tomorrow

Source: cdc.gov
Clinical Resource: Various
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Last Checked: 02/07/14 Link Error: Report It

 

WHO
Malaria

The Global malaria Programme (GMP) is responsible for malaria surveillance, monitoring and evaluation, policy and strategy formulation, technical assistance, and coordination of WHO's global efforts to fight malaria.

Source: who.int
Clinical Resource: Various
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Last Checked: 02/07/14 Link Error: Report It

 

Malaria Chemoprophylaxis: Strategies for Risk Groups

In this paper, we attempt to identify traveler types who are particularly at risk of malaria and to suggest evidence-based strategies for the various risk groups.

Source: cmr.asm.org
Clinical Resource: Journal Article
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Last Checked: 02/07/14 Link Error: Report It

 

What is the most effective and safe malaria prophylaxis during pregnancy?

Chloroquine and mefloquine have superior safety profiles in pregnancy, though all antimalarials are effective for prophylaxis.

Source: jfponline.com
Clinical Resource: Evidence Based Answer to Clinical Question
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Last Checked: 07/05/14 Link Error: Report It

 

Platelets on the Web

This website attempts to provide the latest information on

  • Thrombotic Thrombocytopenic Purpura-Hemolytic Uremic Syndrome (TTP-HUS)
  • Idiopathic Thrombocytopenic Purpura (ITP)
  • Drug-Induced Thrombocytopenia (DITP)
Source: ouhsc.edu
Clinical Resource: Various
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Last Checked: 02/07/14 Link Error: Report It

 

Drugs Affecting Platelet Function

Although some drugs are used specifically for their antiplatelet effects, other commonly used drugs may affect platelet function causing prolongation of the bleeding time. The mechanisms behind the antiplatelet effects of drugs are described below. Drugs that cause thrombocytopenia are not discussed.

Source: druginformation.co.nz
Clinical Resource: Drug Information Service Bulletin
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Last Checked: 02/07/14 Link Error: Report It

 

Disease Management Project
Disorders of Platelet Function and Number

The Disease Management Project is an online medical reference, designed to provide nationally established treatment guidelines for the most commonly seen diseases and conditions.

Chapter Section Links

  • Thrombocytopenias
  • Qualitative platelet disorders
  • Summary
  • References
Source: clevelandclinicmeded.com
Clinical Resource: Medical Reference
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Last Checked: 02/07/14 Link Error: Report It

 

Drug-Induced Thrombocytopenia

Drug-induced thrombocytopenia presents several diagnostic and management challenges. First, it can be difficult to definitively prove that a decrease in platelet count is drug-related, especially in the absence of sufficiently frequent platelet counts to allow for a clearly defined temporal relationship between drug administration and thrombocytopenia.

Source: archivesofpathology.org
Clinical Resource: Journal Article
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Last Checked: 02/07/14 Link Error: Report It

 

Heparin-Induced Thrombocytopenia (HIT)
Frequently Asked Questions

What is HIT? What causes HIT? What is the clinical significance of HIT? How is HIT diagnosed? What are the laboratory features of Type I HIT? What are the laboratory features of Type II HIT? How is HIT treated?

Source: pathology.vcu.edu
Clinical Resource: Frequently Asked Questions
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Last Checked: 02/07/14 Link Error: Report It

 

Heparin-Induced thrombocytopenia: An Update

This article reviews the pathophysiology and provides updates presented in the recently revised American College of Chest Physicians practice guidelines with regard to management of HIT with and without thrombosis.

Source: uspharmacist.com
Clinical Resource: Journal Article
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Last Checked: 02/07/14 Link Error: Report It

 

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