Dopamine Agonists in Parkinson’s DiseaseDopamine agonist drugs are associated with some specific adverse effects that prescribers, patients, and those caring or having responsibility for patients should be aware of.
Managing the major non-motor symptoms of Parkinson’s diseaseNon-motor symptoms such as depression, sleep disturbances or hallucinations are common in Parkinson’s disease (PD), but often these are under-recognised and poorly treated. The frequency of non-motor symptoms usually increases with severity of disease and thus are more likely to affect older patients, many of whom may have had PD for 15 years or more. In this article, Drs Doug MacMahon and Simon McIntosh discuss the major non-motor symptoms.
Recognition and management of neuropsychiatric complications in Parkinson’s diseaseIn this article, we review the primary care approach to the recognition, management and prevention of neuropsychiatric disorders in patients with Parkinson’s disease.
Dopaminergic Medications and Sleep Attacks: A Dangerous Adverse Drug ReactionThe purpose of this Focus is to familiarize prescribers with the phenomenon of dopaminergic antiparkinsonian drug-associated SIAS and to describe proposed strategies for the treatment and prevention of this potentially dangerous ADR.
Drugs to be used with Caution in Parkinson's (for Health Professionals)This brochure is designed to provide information on those drugs that most commonly cause problems for people with Parkinson's disease.
Restless Legs Syndrome Medical Bulletin: A Publication for Healthcare ProvidersThis is our current comprehensive bulletin describing RLS for healthcare providers. Sections include prevalence, diagnosis, and treatment.
Bandolier Knowledge
|
 Source: medicine.ox.ac.uk/bandolier |
| Resource Type: Evidence Based Abstracts |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
This article will discuss current non-pharmacological and pharmacological treatment of RLS, but will focus on the dopaminergic agents ropinirole (Requip®, GlaxoSmithKline) and pramipexole (Mirapex®, Boehringer Ingelheim) which have become first line agents in the treatment of daily primary RLS.
| Source: uiowa.edu |
| Resource Type: Drug Information Service Newsletter |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
Scottish Intercollegiate Guidelines Network (SIGN) Guideline > Management of Patients with Dementia
| Source: sign.ac.uk |
| Resource Type: Guideline |
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| Resource Last Checked: 27/03/13 | Link Error: Report It |
| Source: bap.org.uk |
| Resource Type: Guideline |
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| Source: psych.org |
| Resource Type: Guideline |
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| Source: caalz.org |
| Resource Type: Guideline |
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Welcome to the Alzheimer Europe website. We are a non-governmental organisation aimed at raising awareness of all forms of dementia by creating a common European platform through co-ordination and co-operation between Alzheimer organisations throughout Europe. Alzheimer Europe is also a source of information on all aspects of dementia.
| Source: alzheimer-europe.org |
| Resource Type: Various |
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| Resource Last Checked: 16/05/13 | Link Error: Report It |
| Source: alz.org |
| Resource Type: Various |
| Register to Access Content: No |
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The resources which are available for this therapeutic topic can be accessed via the menu on the left-hand side of the page. The e-learning home page suggests ways in which you may like to use the wide variety of e-learning materials.
| Source: npc.nhs.uk |
| Resource Type: e-Learning |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
The Alzheimer Research Forum, founded in 1996, is the web's most dynamic scientific community dedicated to understanding Alzheimer's disease and related disorders. Access to the web site is free to all. Our editorial priorities are as diverse as the needs of the research community. The web site reports on the latest scientific findings, from basic research to clinical trials; creates and maintains public databases of essential research data and reagents, and produces discussion forums to promote debate, speed the dissemination of new ideas, and break down barriers across the numerous disciplines that can contribute to the global effort to cure Alzheimer's disease.
| Source: alzforum.org |
| Resource Type: Various |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
The Lewy Body Dementia Association (LBDA) is a 501(c)(3) nonprofit organization dedicated to raising awareness of the Lewy body dementias (LBD), supporting patients, their families and caregivers, and promoting scientific advances. The Association's purposes are charitable, educational, and scientific.
| Source: lbda.org |
| Resource Type: Various |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
Reference Guide to Prescribing Cholinesterase Inhibitors
| Source: gov.bc.ca |
| Resource Type: Guide |
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| Resource Last Checked: 16/05/13 | Link Error: Report It |
When drugs from opposing pharmacologic classes are coprescribed, an antagonistic response may occur, reducing the pharmacodynamic response of one or both drugs. The coadministration of anticholinergic agents with cholinergic drugs has been shown to inhibit the efficacy of the cholinergic agents.
| Source: hanstenandhorn.com |
| Resource Type: Journal Article |
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| Resource Last Checked: 16/05/13 | Link Error: Report It |
Elderly people with dementia often tolerate drugs less favorably than healthy older adults. Reasons include increased sensitivity to certain side effects, difficulty with adhering to drug regimens, and decreased ability to recognize and report adverse events. Elderly adults with dementia are also more prone than healthy older persons to develop drug-induced cognitive impairment.
| Source: albany.edu |
| Resource Type: Detail Document |
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| Resource Last Checked: 16/05/13 | Link Error: Report It |
Guidelines for the use of antipsychotics in dementia have been produced by North Staffordshire Combined Healthcare NHS Trust, and have been adopted by the North Staffordshire Area Prescribing Committee.
| Source: medicinesmanagementstoke.nhs.uk |
| Resource Type: Guideline |
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| Resource Last Checked: 16/05/13 | Link Error: Report It |
| Source: sign.ac.uk |
| Resource Type: Guideline |
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| Resource Last Checked: 27/03/13 | Link Error: Report It |
| Source: ilae.org |
| Resource Type: Guideline |
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| Resource Last Checked: 16/05/13 | Link Error: Report It |
American Epilepsy Society Guidelines and Practice Parameters
| Source: aesnet.org |
| Resource Type: Guidelines |
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| Resource Last Checked: 16/05/13 | Link Error: Report It |
American Epilepsy Society Consensus Statements
| Source: aesnet.org |
| Resource Type: Consensus Statements |
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| Resource Last Checked: 16/05/13 | Link Error: Report It |
Research | Articles | Anti-epileptic drugs | News | Conferences | Resources and training | Links | Dravet syndrome
| Source: epilepsysociety.org.uk |
| Resource Type: Various |
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| Resource Last Checked: 16/05/13 | Link Error: Report It |
An online resource for healthcare professionals to learn about epilepsy and seizures, co-existing disorders, specialized populations, and diagnosis and treatment for epilepsy. Visit our site for daily research and medical news about epilepsy, commentary from leading voices in the field, and opinions on controversial topics surrounding epilepsy research and treatment.
What you will find on epilepsy.com/professionals:
| Source: epilepsy.com |
| Resource Type: Various |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
The Merck Manual for Health Care Professionals
Seizure Disorders
| Source: merckmanuals.com |
| Resource Type: Manual |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
Chapter Section Links
| Source: clevelandclinicmeded.com |
| Resource Type: Medical Reference |
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| Resource Last Checked: 16/05/13 | Link Error: Report It |
The resources which are available for this therapeutic topic can be accessed via the menu on the left-hand side of the page. The e-learning home page suggests ways in which you may like to use the wide variety of e-learning materials.
| Source: npc.nhs.uk |
| Resource Type: e-Learning |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
This guide takes a problem-based approach to care. It does not cover every aspect of care of older people with possible epilepsy. Nor does it cover every aspect of care of other problems that can cause diagnostic confusion (syncope, transient ischemic attack (TIA), simple falls, delirium or sleep disorders). However, the guideline does focus on key steps in the differential diagnosis of a patient with possible epilepsy; key features of the specific treatment of established epilepsy and a basic strategy for care for older people presenting with symptoms that could be due to epilepsy.
| Source: epilepsyscotland.org.uk |
| Resource Type: Guide |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
| Source: ilae.org |
| Resource Type: Database |
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| Resource Last Checked: 16/05/13 | Link Error: Report It |
Concise guide to the currently available drug options in epilepsy
Our Drug review of epilepsy provides an overview of the wide range of first-line, second-line and alternative antiepileptic drugs available, followed by a review of the prescription data and sources of further information.
| Source: eu.wiley.com |
| Resource Type: Journal Article |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
Epilepsy Action Position Statement on the Consistency of Supply
| Source: epilepsy.org.uk |
| Resource Type: Position Statement |
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| Resource Last Checked: 25/02/13 | Link Error: Report It |
Epilepsy Society of Australia Position Statement: Generic drug use in epilepsy
| Source: epilepsy-society.org.au |
| Resource Type: Position Statement |
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| Resource Last Checked: 25/02/13 | Link Error: Report It |
North of Tyne Area Prescribing Committee Guideline on prescribing generic Anti-epileptic Drugs
| Source: northoftyneapc.nhs.uk |
| Resource Type: Guideline |
| Register to Access Content: No |
| Resource Last Checked: 25/02/13 | Link Error: Report It |
Generic AEDs: Current Standards and Recommendations
Switching AED Formulations: Defining the Issues
Understanding the Ramifications of Switching Among AEDs: What Are the Data?
| Source: utasip.com |
| Resource Type: Review Articles and Roundtable Discussion |
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| Resource Last Checked: 25/02/13 | Link Error: Report It |
Comprehensive reviews of interactions involving AEDs have been published recently. The purpose of the present review is to highlight those which, because of their frequency or magnitude, are especially likely to have adverse clinical consequences.
| Source: eu.wiley.com |
| Resource Type: Journal Article |
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| Resource Last Checked: 16/05/13 | Link Error: Report It |
| Source: fsrh.org |
| Resource Type: Statement |
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| Source: fsrh.org |
| Resource Type: Statement |
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In this paper an overview will be given of how knowledge of pharmacokinetic mechanisms determines which pharmacokinetic characteristics an AED should have. Various clinical factors such as age, underlying physiological conditions and drug interactions will also affect the pharmacokinetics and efficacy of AED medication. It will be shown how by anticipating changes in pharmacokinetics due to possible drug interactions, or alterations in one of the pharmacokinetic parameters, adverse effects and breakthrough seizures may be averted and aid in the choice of optimal AED therapy for each patient.
| Source: mcppnet.org |
| Resource Type: Journal Article |
| Register to Access Content: No |
| Resource Last Checked: 14/02/13 | Link Error: Report It |
This review examines the elusive concept of therapeutic AED blood levels and potential uses and abuses of blood level monitoring, reinforcing appropriate uses for blood levels to ensure compliance and adjust for altered AED pharmacokinetics in the context of aging and disease states, pregnancy, or drug interactions.
| Source: nih.gov |
| Resource Type: Journal Article |
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| Resource Last Checked: 14/02/13 | Link Error: Report It |
In this article we apply to phenytoin the criteria that must be fulfilled in part or in full before the measurement of its plasma concentration can be considered worth while.
| Source: europepmc.org |
| Resource Type: Journal Article |
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| Resource Last Checked: 16/05/13 | Link Error: Report It |
Phenytoin carries a special risk of dose-related toxicity, due to its saturation (zero-order) pharmacokinetics: serum levels often rise much more than would ordinarily be expected after initiating or increasing a maintenance dose. This predicts a vulnerability to toxicity, but does not predict exactly when this will occur in the individual.
| Source: jfponline.com |
| Resource Type: Journal Article |
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| Resource Last Checked: 14/02/13 | Link Error: Report It |
This Q&A discusses the potential problems of changing between oral phenytoin sodium capsules and tablets.
| Source: evidence.nhs.uk |
| Resource Type: Medicines Question and Answer |
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| Resource Last Checked: 04/04/13 | Link Error: Report It |
This article describes the application of therapeutic drug monitoring to achieve optimal dosing of phenytoin in an elderly patient with co-morbid conditions.
| Source: clinicalpharmacy.org.uk |
| Resource Type: Journal Article |
| Register to Access Content: Yes - registration is FREE to healthcare professionals |
| Resource Last Checked: 14/02/13 | Link Error: Report It |
The antiepileptic phenytoin requires therapeutic drug monitoring during its use to ensure adequate seizure control and to avoid toxicity.
| Source: auspharmlist.net.au |
| Resource Type: Pharmacy E-Bulletin |
| Register to Access Content: No |
| Resource Last Checked: 14/02/13 | Link Error: Report It |
Phenytoin is a commonly used anticonvulsant but is one of the most difficult drugs to dose appropriately. It has a narrow therapeutic range and, because of saturable metabolism, small dose increases can result in disproportionately large increases in serum concentrations.
| Source: druginformation.co.nz |
| Resource Type: Drug Information Service Bulletin |
| Register to Access Content: No |
| Resource Last Checked: 14/02/13 | Link Error: Report It |
To clarify the two correct methods of administering IV phenytoin, the Medicines Governance Project Team have prepared the enclosed administration summary sheet.
| Source: medicinesgovernanceteam.hscni.net |
| Resource Type: Memo and Update |
| Register to Access Content: No |
| Resource Last Checked: 18/02/13 | Link Error: Report It |
The North American AED (antiepileptic drug) Pregnancy Registry was established in 1997 for pregnant women in the United States and Canada at the Massachusetts General Hospital in Boston, Massachusetts. It was established with funds provided by six companies that manufacture "old" and "new" anticonvulsant drugs. The major objective is to obtain and publish information on the frequency of major malformations, such as heart defects, spina bifida and cleft lip, among infants whose mothers had taken one or more AEDs to prevent seizures or to treat any other medical condition. The highest priority was new information on the many "new" AEDs marketed in the past 10 years.
| Source: aedpregnancyregistry.org |
| Resource Type: Various |
| Register to Access Content: No |
| Resource Last Checked: 20/03/13 | Link Error: Report It |
In this article, Dr Hart discusses the special precautions that need to be taken when caring for women with epilepsy before and during pregnancy, including preconception counselling, adjustment of antiepileptic drugs and monitoring of the mother and fetus.
| Source: eu.wiley.com |
| Resource Type: Journal Article |
| Register to Access Content: No |
| Resource Last Checked: 20/03/13 | Link Error: Report It |
| Source: plymouth.ac.uk |
| Resource Type: Guideline |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
Epilepsy patients who are diagnosed with clinical depression are often not treated with antidepressant drugs. There are a number of arguments for avoiding antidepressants in a person with active epilepsy; but there also are irrational worries. On the patient’s side, there is often the fundamental problem that a diagnosis of depression cannot be accepted because psychiatric disorders are seen as even more stigmatizing than epilepsy. However, for the physician, who most often has little or no psychiatric training, there is often an inappropriate fear of using antidepressants because of proconvulsive properties and of kinetic and dynamic interactions with antiepileptic drugs (AEDs).
| Source: eu.wiley.com |
| Resource Type: Journal Article |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
The incidence of antidepressant induced seizures ranges from 0.1–4.0%, with the greatest risk being in patients with identifiable risk factors, as listed below. The mechanisms by which antidepressants cause seizures are unclear.
| Source: auspharmlist.net.au |
| Resource Type: Pharmacy E-Bulletin |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
The purpose of this article is to provide a concise overview of pharmacokinetic interactions between psychotropic agents and antiepileptic drugs (AEDs).
| Source: eu.wiley.com |
| Resource Type: Journal Article |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
Suggestions for Management of Anticonvulsant-Antiretroviral Interactions in HIV
| Source: hivclinic.ca |
| Resource Type: |
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| Resource Last Checked: 16/05/13 | Link Error: Report It |
Essential oils, obtained from plants, are widely used in aromatherapy and are included in some medicines. Healthcare professionals are reminded that these substances, when administered orally or topically, can rarely cause seizures in young children and in those patients with epilepsy.
| Source: medsafe.govt.nz |
| Resource Type: Prescriber Update Article |
| Register to Access Content: No |
| Resource Last Checked: 18/03/13 | Link Error: Report It |
Scottish Intercollegiate Guidelines Network (SIGN) Guideline > Management of Patients With Stroke or TIA: Assessment, Investigation, Immediate Management and Secondary Prevention
| Source: sign.ac.uk |
| Resource Type: Guideline |
| Register to Access Content: No |
| Resource Last Checked: 27/03/13 | Link Error: Report It |
| Source: sign.ac.uk |
| Resource Type: Guideline |
| Register to Access Content: No |
| Resource Last Checked: 27/03/13 | Link Error: Report It |
| Source: sign.ac.uk |
| Resource Type: Guideline |
| Register to Access Content: No |
| Resource Last Checked: 27/03/13 | Link Error: Report It |
American Heart Association/American Stroke Association Statements and Guidelines
| Source: my.americanheart.org |
| Resource Type: Statements and Guidelines |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
European Stroke Organization Guideline Update – January 2009
The ESO Guidelines have been updated with regard to thrombolytic therapy. The modifications were discussed and prepared at the Karolinska Stroke Update Meeting, November 2008, and have been approved by the ESO Guideline Committee and the ESO Executive Committee.
| Source: eso-stroke.org |
| Resource Type: Guideline and Update |
| Register to Access Content: No |
| Resource Last Checked: 22/04/13 | Link Error: Report It |
| Source: eso-stroke.org |
| Resource Type: Guideline |
| Register to Access Content: No |
| Resource Last Checked: 22/04/13 | Link Error: Report It |
Canadian Best Practice Recommendations for Stroke Care
The Canadian Best Practice Recommendations for Stroke Care are intended to provide up-to-date evidence-based guidelines for the prevention and management of stroke.
| Source: strokebestpractices.ca |
| Resource Type: Recommendations |
| Register to Access Content: No |
| Resource Last Checked: 22/04/13 | Link Error: Report It |
The Internet Stroke Center provides health professionals with multiple tools and educational presentations about stroke assessment, stroke treatment and management. Physicians and medical students will also find a library of more than 1800 images of cerebrovascular and neurological diseases.
| Source: strokecenter.org |
| Resource Type: Various |
| Register to Access Content: No |
| Resource Last Checked: 22/04/13 | Link Error: Report It |
In these pages are collected the stories from Bandolier relating to stroke.
| Source: medicine.ox.ac.uk/bandolier |
| Resource Type: Evidence Based Abstracts |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
The resources which are available for this therapeutic topic can be accessed via the menu on the left-hand side of the page. The e-learning home page suggests ways in which you may like to use the wide variety of e-learning materials.
| Source: npc.nhs.uk |
| Resource Type: e-Learning |
| Register to Access Content: No |
| Resource Last Checked: 22/04/13 | Link Error: Report It |
| Source: eso-stroke.org |
| Resource Type: Frequently Asked Questions |
| Register to Access Content: No |
| Resource Last Checked: 22/04/13 | Link Error: Report It |
Massachusetts General Hospital
Stroke Service
Acute Ischemic Stroke
The protocols and guidelines we use to treat acute ischemic stroke.
| Source: massgeneral.org |
| Resource Type: Various |
| Register to Access Content: No |
| Resource Last Checked: 22/04/13 | Link Error: Report It |
SPARC - Stroke Prevention in Atrial Fibrillation Risk Tool
for estimating risk of stroke and benefits & risks of antithrombotic therapy in patients with chronic atrial fibrillation
| Source: sparctool.com |
| Resource Type: Tool |
| Register to Access Content: No |
| Resource Last Checked: 22/04/13 | Link Error: Report It |
This tool can predict a patient's stroke risk 90 days after a Transient Ischemic Attack (TIA).
| Source: bmc.org |
| Resource Type: Tool |
| Register to Access Content: No |
| Resource Last Checked: 22/04/13 | Link Error: Report It |
The risk of recurrent stroke is as high as 43% over 10 years. Antiplatelet therapy is an accepted strategy for reduction in this risk. The common choices are aspirin, aspirin plus extended release Dipyridamole (ASA-ESDP), and clopidogrel. When selecting an antiplatelet there should be consideration of co-morbidities (especially acute coronary disease), tolerance, and recurrence of stroke while on an antiplatelet.
| Source: auspharmlist.net.au |
| Resource Type: Pharmacy E-Bulletin |
| Register to Access Content: No |
| Resource Last Checked: 22/04/13 | Link Error: Report It |
This document has been produced by the Joint British Diabetes Societies for Inpatient Care (JBDS – IP) on behalf of Diabetes UK, the Association of British Clinical Diabetologists (ABCD), and the Diabetes Inpatient Specialist Nurse (DISN) UK Group, in collaboration with NHS Diabetes and the Primary Care Diabetes Society (PCDS).
| Source: diabetologists-abcd.org.uk |
| Resource Type: Guideline |
| Register to Access Content: No |
| Resource Last Checked: 22/04/13 | Link Error: Report It |
This article reviews antiplatelet and anticoagulant treatments used for prevention of stroke in patients with atrial fibrillation, with reference to evidence for risk of bleeding, and discusses risk stratification for starting warfarin.
| Source: gmjournal.co.uk |
| Resource Type: Journal Article |
| Register to Access Content: No |
| Resource Last Checked: 05/03/13 | Link Error: Report It |
| Source: bash.org.uk |
| Resource Type: Guideline |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
Welcome to this electronic document, which summarises the new Migraine in Primary Care Advisors (MIPCA) guidelines for the management of migraine in primary care in a dynamic and interactive form. MIPCA has devised rational, evidence-based guidelines for the management of migraine that are categorised into several clinically appropriate areas:
| Source: mipca.org.uk |
| Resource Type: Guideline |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
In this issue
Introduction and background
Management of acute migraine
Triptans
Prophylaxis of migraine
Other management issues
| Source: hscbusiness.hscni.net |
| Resource Type: Bulletin |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
| Source: sign.ac.uk |
| Resource Type: Guideline |
| Register to Access Content: No |
| Resource Last Checked: 27/03/13 | Link Error: Report It |
Two years after the publication of the 2nd Edition of The International Headache Classification (ICHD-2), we are now ready to launch a web based edition. This web based version has many facilities that are not present in the printed version or a simple electronic file.
Since a Headache Classification cannot be learned by heart, it is of immense value that doctors all over the world are now able to go on the web and look after whatever question they may have regarding ICHD-2.
Table of Contents
Part I: The Primary Headaches
Part II: The Secondary Headaches
Part III: Cranial Neuralgias, Central and Primary Facial Pain And Other Headaches
| Source: ihs-classification.org |
| Resource Type: Classification |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
Headache Management
Western Sussex Hospitals NHS
The aims of these guidelines are: to make a diagnosis and initiate treatment where possible and to assess urgency of referral if indicated.
| Source: gp.westernsussexhospitals.nhs.uk |
| Resource Type: Guideline |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
The Bandolier migraine site contains stories from Bandolier , plus abstracts of systematic reviews, meta-analyses, or other studies about migraine.
| Source: medicine.ox.ac.uk/bandolier |
| Resource Type: Evidence Based Abstracts |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
The resources which are available for this therapeutic topic can be accessed via the menu on the left-hand side of the page. The e-learning home page suggests ways in which you may like to use the wide variety of e-learning materials.
| Source: npc.nhs.uk |
| Resource Type: e-Learning |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
The American Headache Society (AHS) welcomes you to Brainstorm—The Primary Care Migraine Partnership’s collaborative, interactive educational program. The Primary Care Migraine Partnership is an innovative educational program designed by primary care physicians and neurologists for primary care physicians. This dynamic program results from an extensive needs assessment, including a comprehensive review of the primary care literature and more than 80 hours of interviews with primary care physicians regarding the challenges faced in treating migraine patients.
| Source: americanheadachesociety.org |
| Resource Type: CE / CPD / CME / Learning |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
Downloadable Fact Sheets on a Number of Topics of Importance in Headache Medicine
| Source: americanheadachesociety.org |
| Resource Type: Factsheets |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
"This is a description of an individual expert practitioner's approach, presented to give the learner some practical ideas.
| Source: americanheadachesociety.org |
| Resource Type: Treatment Recommendation |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
These guidelines were developed by the NSW Therapeutic Assessment Group Inc (NSW TAG).
| Source: ciap.health.nsw.gov.au/nswtag |
| Resource Type: Guideline |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
Off-Label Drug Uses
Lisinopril: Prevention of Migraine (Adults)
| Source: thomasland.com |
| Resource Type: Journal Article |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
Off-Label Drug Uses
Olmesartan: Migraine Prevention
| Source: thomasland.com |
| Resource Type: Journal Article |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
The FDA has issued a Public Health Advisory that warns of possible serotonin syndrome in patients receiving 5-hydroxytryptamine receptor agonists (triptans) together with either selective serotonin reuptake inhibitors (SSRIs) or selective serotonin norepinephrine reuptake inhibitors (SNRIs).
| Source: hanstenandhorn.com |
| Resource Type: Journal Article |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
Here, we summarize available data on MOH, including clinical features, drugs used in withdrawal, as well as withdrawal strategies that have been described in the literature. We also include a detailed description of an in-patient and out-patient withdrawal procedure, reflecting personal experience and opinion of the authors.
| Source: actaneurologica.be |
| Resource Type: Journal Article |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
Patients commonly take analgesics for headaches. However, chronic use of analgesics for headache can cause headache as a withdrawal phenomenon. Epidemiological data suggest that 4% of the population misuse pain medication, and that a minimum 1% of the general population in Europe, North America and Asia suffer from medication overuse headache.
| Source: australianprescriber.com |
| Resource Type: Journal Article |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
The MS Society works with professionals to improve the lives of people affected by MS.
Find resources, events and funding to develop and improve services for people with MS.
| Source: mssociety.org.uk |
| Resource Type: Various |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
| Source: canadianpainsociety.ca |
| Resource Type: Guideline |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
Neuropathic pain is caused by damage to or malfunction of the nervous system and is divided into"peripheral"(originating in the peripheral nervous system) and"central"(originating in the brain or spinal cord.
| Source: paincommunitycentre.org |
| Resource Type: Various |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
This article reviews how to classify a patient’s pain on the basis of the clinical picture, discusses the physiology of pain, and provides several approaches to managing common neuropathic pain syndromes, with two cases to illustrate the art and the science of treatment.
| Source: ccjm.org |
| Resource Type: Journal Article |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
Pharmacologic Treatment of Neuropathic Pain
| Source: paineducation.vcu.edu |
| Resource Type: Table |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
Interest and research into the mechanisms and treatment of neuropathic pain have increased during recent years, but current treatment is still far from satisfactory. The European Federation of Neurological Societies (EFNS) Task Force recently published guidelines for the pharmacological treatment of neuropathic pain. However, no particular consideration is given as to how the recommendations are applicable to the elderly population. This paper will review the guidelines in relation to this population and evaluate the existing evidence relating to the use of these drugs in older persons.
| Source: nih.gov |
| Resource Type: Journal Article |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
A variety of pharmacologic agents from different therapeutic classes have been used for NP treatment. Even so, only 40-60% of patients obtain even partial pain relief for NP with existing pharmacologic agents. Methodology, small sample sizes, short duration studies, lack of head to head trials, and variability in drug classes for treatment of different types of NP limit comparative analysis of many medications.
| Source: oregonstate.edu |
| Resource Type: Newsletter |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
This paper reviews the pharmacology and clinical effectiveness of gabapentin in the treatment of neuropathic pain.
| Source: eapcnet.eu |
| Resource Type: Journal Article |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
This guidance was developed to identify the therapeutic indications and dosage regimens of gabapentin for which there are sufficient documentation of efficacy and safety and to define parameters for an adequate trial after which gabapentin should be discontinued if there has been no or little clinical benefit.
| Source: pbm.va.gov |
| Resource Type: Guidance |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
Pregabalin is the first “adjuvant” analgesic whose primary indication is treatment of neuropathic pain. But is pregabalin really unique? Is it more effective, safer, easier to use or less expensive than current alternatives? Pregabalin’s closest comparator is gabapentin, an anticonvulsant that has been increasingly used for neuropathic pain in recent years.
| Source: stacommunications.com |
| Resource Type: Journal Article |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
Converting from Gabapentin to Pregabalin
Below are some suggested conversion regimes. Each step could be 3 - 7 days.
| Source: painclinic.org |
| Resource Type: Table |
| Register to Access Content: No |
| Resource Last Checked: 04/04/13 | Link Error: Report It |
Guidelines for General Practitioners on Treatment of Pain in Post-Herpetic Neuralgia
| Source: shinglessupport.org.uk |
| Resource Type: Guideline |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
Guide for the Prevention and Treatment of PHN
Postherpetic neuralgia (PHN), a disabling consequence of herpes zoster (HZ) caused by the reactivation of the varicella-zoster infection, can be effectively prevented with the Zostavax vaccine and treated with several pharmacologic therapies.
| Source: painknowledge.org |
| Resource Type: Guide |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
The objective of this supplement to Clinical Infectious Diseases is to improve the care of patients with HZ by providing practical, evidence-based recommendations that take into account clinical efficacy, adverse effects, impact on quality of life, and costs of treatment. Pharmacologic management is emphasized, because few nonpharmacologic approaches have been evaluated in randomized controlled trials. These recommendations apply only to the acute phase of HZ; detailed recommendations for the treatment of postherpetic neuralgia (PHN), the most common complication of HZ, appear elsewhere. We describe the pathogenesis, epidemiological aspects, clinical aspects, and complications of HZ, and then we review the literature on the treatment of HZ and present specific treatment recommendations.
| Source: cid.oxfordjournals.org |
| Resource Type: Supplement Article |
| Register to Access Content: No |
| Resource Last Checked: 19/03/13 | Link Error: Report It |
This review focuses on the clinical manifestations and treatment of HZ and PHN, as well as the appropriate use of the HZ vaccine.
| Source: mayoclinicproceedings.org |
| Resource Type: Journal Article |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
Here, we provide an overview of the new vaccine and introduce clinicians to a new clinical paradigm — the prevention of HZ. We also apply current opinion and evidence to the management of HZ.
| Source: mja.com.au |
| Resource Type: Journal Article |
| Register to Access Content: No |
| Resource Last Checked: 19/03/13 | Link Error: Report It |
| Source: rcog.org |
| Resource Type: Scientific Impact Paper |
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| Resource Last Checked: 18/03/13 | Link Error: Report It |
This review will discuss risk factors for development of NTDs, folic acid sources, doses, and duration of therapy.
| Source: cph.sagepub.com |
| Resource Type: Journal Article |
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| Resource Last Checked: 18/03/13 | Link Error: Report It |
The causes of nausea and vomiting are multifarious and a full clinical history is required before commencing treatment. Our Drug review discusses the diagnosis and the available drug options and their properties, followed by sources of further information.
| Source: eu.wiley.com |
| Resource Type: Journal Article |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
An understanding of the mechanisms of action of the drugs used to treat nausea and vomiting is important when selecting the best treatment for the patient. The drugs used vary in their efficacy depending on the cause of emesis, as described in this article
Nausea and vomiting are biological defence mechanisms, associated with a variety of stimuli and conditions. This article explains some of the common causes of nausea and vomiting and the complications that can arise
| Source: pjonline.com |
| Resource Type: Journal Articles |
| Register to Access Content: Yes - content available to members of the RPS and paid subscribers |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
| Source: hpa.org.uk |
| Resource Type: Guideline |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
| Source: sign.ac.uk |
| Resource Type: Guideline |
| Register to Access Content: No |
| Resource Last Checked: 27/03/13 | Link Error: Report It |
| Source: idsociety.org |
| Resource Type: Guideline |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
Meningitis Trust
Meningitis information
| Source: meningitis-trust.org |
| Resource Type: Various |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
| Source: idsociety.org |
| Resource Type: Guideline |
| Register to Access Content: No |
| Resource Last Checked: 16/05/13 | Link Error: Report It |
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